國家衛生研究院 NHRI:Item 3990099045/10680
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    題名: Neural stem cells promote nerve regeneration through IL12-induced schwann cell differentiation
    作者: Chiu, IM;Lee, DC;Chen, JH
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Regeneration of injured peripheral nerves is a slow, complicated process that could be improved by implantation of neural stem cells (NSCs) or nerve conduit. Implantation of NSCs along with conduits promotes the regeneration of damaged nerve, likely because (i) conduit supports and guides axonal growth from one nerve stump to the other, while preventing fibrous tissue ingrowth and retaining neurotrophic factors; and (ii) implanted NSCs differentiate into Schwann cells and maintain a growth factor enriched microenvironment, which promotes nerve regeneration. In this study, we identified IL12p80 (homodimer of IL12p40) in the cell extracts of implanted nerve conduit combined with NSCs by using protein antibody array and Western blotting analyses. Levels of IL12p80 in these conduits are 1.6-fold higher than those in conduits without NSCs. In the sciatic nerve injury mouse model, implantation of NSCs combined with nerve conduit and IL12p80 improves motor recovery and increases the diameter up to 4.5-fold, at the medial site of the regenerated nerve. In vitro study further revealed that IL12p80 stimulates the Schwann cell differentiation of mouse NSCs through the phosphorylation of signal transducer and activator of transcription 3 (Stat3). These results suggest that IL12p80 can trigger Schwann cell differentiation of mouse NSCs through Stat3 phosphorylation and, in turn, enhance the functional recovery and increase the diameter of regenerated nerves in a mouse sciatic nerve injury model.
    日期: 2017-04
    關聯: FASEB Journal. 2017 Apr;31(1, Suppl. 1):Abstract number 936.5.
    Link to: http://www.fasebj.org/content/31/1_Supplement/936.5.abstract?sid=bc647e39-2896-4fe4-82bd-3cd6c0a92afa
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000405461402788
    顯示於類別:[邱英明] 會議論文/會議摘要

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