國家衛生研究院 NHRI:Item 3990099045/10619
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 917083      在线人数 : 1517
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10619


    题名: Development of Ce-doped TiO2 activated by X-ray irradiation for alternative cancer treatment
    作者: Yang, CC;Sun, YJ;Chung, PH;Chen, WY;Swieszkowski, W;Tian, W;Lin, FH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Photodynamic therapy (PDT) is limited by its penetration depth because of the selection of photosensitizer and light source. In this study, Ce-doped TiO2 (TiO2:Ce) was synthesized by a modified sol-gel method to act as a photosensitizer activated by low-dose X-rays, less harmful than ionizing radiation, to generate intracellular reactive oxygen species (ROS). The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-irradiated TiO2:Ce to induce cell death. The cell viability significantly decreased with TiO2:Ce exposure under low-dose X-ray irradiation. An LDH assay showed that intracellular TiO2:Ce under X-ray irradiation was cytotoxic to A549 cancer cells. TiO2:Ce produced significant ROS under low-dose X-ray irradiation and promoted apoptosis/necrosis of A549 cancer cells. TiO2:Ce can enhance the efficacy of X-ray-induced PDT, and tumor growth was inhibited in vivo. The mechanisms underlying ROS generation by TiO2:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed.
    日期: 2017-10
    關聯: Ceramics International. 2017 Oct;43(15):12675-12683.
    Link to: http://dx.doi.org/10.1016/j.ceramint.2017.06.149
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0272-8842&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000408287900148
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021125562
    显示于类别:[林峯輝] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP85021125562.pdf1186KbAdobe PDF399检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈