國家衛生研究院 NHRI:Item 3990099045/10554
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10554


    Title: trans-stilbene C-glycosides: Synthesis by a microwave-assisted heck reaction and evaluation of the SGLT-2 inhibitory activity
    Authors: KumarPonnapalli, K;KumarAdak, A;Das, A;Song, JS;Wu, SH;Sun, CM;Lin, CC
    Contributors: Institute of Biotechnology and Pharmaceutical Research
    Abstract: A protocol for the microwave-assisted Heck coupling reaction of C-aryl glycosides and styrenes has been developed for the synthesis of mono- and bis(C-glycoside) stilbenes. This method exclusively provides C-glycoside trans-stilbenes in good yields. The Pd-catalyzed Heck coupling reaction was successfully applied to various functionalized C-glycosyl aryl iodides and various substituted styrenes to deliver several C-glycoside trans-stilbenes with high selectivity. The obtained C-glycosyl trans-stilbenes were also examined for human SGLT-2 inhibitory activity.
    Date: 2017-09
    Relation: Asian Journal of Organic Chemistry. 2017 Sep;6(9):1308-1321.
    Link to: http://dx.doi.org/10.1002/ajoc.201700148
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2193-5807&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000410778400026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85020547965
    Appears in Collections:[Others] Periodical Articles

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