國家衛生研究院 NHRI:Item 3990099045/10551
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    題名: Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential
    作者: Chang, HS;Lin, CH;Hsiao, PY;Peng, HT;Lee, SJ;Cheng, MJ;Chen, IS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Six new compounds including three lignanoids: reevesiacoumarin (1), reevesic acid (2), and reevesilignan (3), and three terpenoids: reevesiterpenol A (4), reevesiterpenol B (5), and 3 alpha, 27-di-O-trans-caffeoylbetulinic acid (6), along with 40 known compounds were isolated from the root and stem of Reevesia formosana (Sterculiaceae). The structures of 1-6 were determined by spectroscopic techniques. Bioassays for the cytotoxicities of MCF-7, NCI-H460, and HepG2 cancer cell lines led to finding three cardenolides: strophanthojavoside (31) and ascleposide (32) with IC50 < 1 mu M and strophalloside (33) displayed selective cytotoxicity to NCI-H460 with IC50 0.62 +/- 0.06 mu M as well. 3 alpha, 27-Di-O-trans-caffeoylbetulinic acid (6) and secoisolariciresinol (13) also showed weak but selective cytotoxicity to NCI-H460 and HepG2 cancer cell lines, respectively.
    日期: 2017-05-22
    關聯: RSC Advances. 2017 May 22;7(43):27040-27047.
    Link to: http://dx.doi.org/10.1039/c7ra04255h
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2046-2069&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000401975700065
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021689384
    顯示於類別:[李秀珠] 期刊論文

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