國家衛生研究院 NHRI:Item 3990099045/10512
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    題名: Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma
    作者: Ke, HL;Li, WM;Lin, HH;Hsu, WC;Hsu, YL;Chang, LL;Huang, CN;Li, CC;Chang, HP;Yeh, HC;Li, CF;Wu, WJ
    貢獻者: National Institute of Cancer Research
    摘要: Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1 alpha (HIF-1 alpha) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1a was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1 alpha is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1 alpha are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.
    日期: 2017-05-11
    關聯: International Journal of Medical Sciences. 2017 May 11;14(6):578-584.
    Link to: http://dx.doi.org/10.7150/ijms.15699
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1449-1907&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000401121900009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85019641728
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