國家衛生研究院 NHRI:Item 3990099045/10489
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    题名: Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
    作者: Howson, JMM;Zhao, W;Barnes, DR;Ho, WK;Young, R;Paul, DS;Waite, LL;Freitag, DF;Fauman, EB;Salfati, EL;Sun, BB;Eicher, JD;Johnson, AD;Sheu, WHH;Nielsen, SF;Lin, WY;Surendran, P;Malarstig, A;Wilk, JB;Tybjaerg-Hansen, A;Rasmussen, KL;Kamstrup, PR;Deloukas, P;Erdmann, J;Kathiresan, S;Samani, NJ;Schunkert, H;Watkins, H;Do, R;Rader, DJ;Johnson, JA;Hazen, SL;Quyyumi, AA;Spertus, JA;Pepine, CJ;Franceschini, N;Justice, A;Reiner, AP;Buyske, S;Hindorff, LA;Carty, CL;North, KE;Kooperberg, C;Boerwinkle, E;Young, K;Graff, M;Peters, U;Absher, D;Hsiung, CA;Lee, WJ;Taylor, KD;Chen, YH;Lee, IT;Guo, X;Chung, RH;Hung, YJ;Rotter, JI;Juang, JJ;Quertermous, T;Wang, TD;Rasheed, A;Frossard, P;Alam, DS;Majumder, AAS;Di Angelantonio, E;Chowdhury, R;Chen, YI;Nordestgaard, BG;Assimes, TL;Danesh, J;Butterworth, AS;Saleheen, D
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 x 10-8, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms.
    日期: 2017-07
    關聯: Nature Genetics. 2017 Jul;49(7):1113-1119.
    Link to: http://dx.doi.org/10.1038/ng.3874
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1061-4036&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000404253300022
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021756461
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