國家衛生研究院 NHRI:Item 3990099045/10449

NHRI > National Institute of Infectious Diseases and Vaccinology > Joe Yen-Hung Chow > Periodical Articles > Item 3990099045/10449

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10449

Title:	Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype
Authors:	Chang, HW;Lin, ZM;Wu, MJ;Wang, LY;Chow, YH;Jiang, SS;Ch'ang, HJ;Chang, VHS
Contributors:	Division of Vaccine Research and Development;National Institute of Cancer Research
Abstract:	Developing lung cancer in mouse models that display similarities of both phenotype and genotype will undoubtedly provide further and better insights into lung tumor biology. Moreover, a high degree of pathophysiological similarity between lung tumors from mouse models and their human counterparts will make it possible to use these mouse models for preclinical tests. Ovine pulmonary adenocarcinomas (OPAs) present the same symptoms as adenocarcinomas in humans and are caused by a betaretrovirus. OPAs have served as an exquisite model of carcinogenesis for human lung adenocarcinomas. In this study, we characterized the histopathology and transcriptome profiles of a jaagsiekte sheep retrovirus (JSRV)-envelope protein (Env) transgenic mouse model with spontaneous lung tumors, and associations of the transcriptome profiles with tumor invasion/metastasis, especially the phenomenon of the epithelial-mesenchymal transition (EMT). Genetic information obtained from an expression array was analyzed using an ingenuity pathways analysis (IPA) and human disease database (MalaCards). By careful examination, several novel EMT-related genes were identified from tumor cells using RT-qPCR, and these genes also scored high in MalaCards. We concluded that the JSRV-Env mouse model could serve as a spontaneous lung adenocarcinoma model with a metastatic phenotype, which will benefit the study of early-onset and progression of lung adenocarcinoma. In addition, it can also be a valuable tool for biomarkers and drug screening, which will be helpful in developing intervention therapies.
Date:	2017-04-18
Relation:	PLoS ONE. 2017 Apr 18;12(4):Article number e0175586.
Link to:	http://dx.doi.org/10.1371/journal.pone.0175586
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000399875200029
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017622891
Appears in Collections:	[Joe Yen-Hung Chow] Periodical Articles [Hui-Ju Mandy Ch'ang] Periodical Articles [Shih-Sheng Jiang] Periodical Articles

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