國家衛生研究院 NHRI:Item 3990099045/10423

NHRI > Institute of Molecular and Genomic Medicine > Hsin-Ling Hsu > Conference Papers/Meeting Abstract > Item 3990099045/10423

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10423

Title:	Oncogenic MCT-1 activation deregulates oxidative metabolism and promotes lung tumor progression and metastasis
Authors:	Tseng, HY;Chen, YA;Jen, JY;Wang, YC;Hsu, HL
Contributors:	Institute of Molecular and Genomic Medicine
Abstract:	Multiple copies in T-cell malignancy 1 (MCT-1) is involved in transcription regulation and translation initiation. We have identified that MCT-1 plays important roles in cell transformation and survival, catastrophic mitosis and genomic instability. Enhanced MCT-1 activity decreases p53 promoter function, protein stability and activity, thereby overexpressing MCT-1 further promotes tumorigenicity in a p53-null background. Enhanced MCT-1 activation induces SHCs (Src homology 2 domain containing transforming proteins) that transmit EGFR signaling to extracellular-regulated kinase (ERK) and AKT pathway. Here, we identify a novel carcinoma metabolism pathway involving MCT-1-YY1-EGFR-MnSOD axis which confers oxidative resistance, changes tumor microenvironments and promotes tumor development. Inhibiting this oncogenic pathway may be a novel clinical intervention approach to prevent tumor progression and metastasis.
Date:	2017-03
Relation:	Cancer Research. 2017 Mar;77(Suppl. 6):Meeting Abstract A30.
Link to:	http://dx.doi.org/10.1158/1538-7445.Transcontrol16-A30
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000397860300022
Appears in Collections:	[Hsin-Ling Hsu] Conference Papers/Meeting Abstract

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