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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/10375
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| Title: | Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwan |
| Authors: | Chen, YT;Lai, YC;Tan, MC;Hsieh, LY;Wang, JT;Shiau, YR;Wang, HY;Lin, AC;Lai, JF;Huang, IW;Lauderdale, TL |
| Contributors: | Division of Infectious Diseases;Institute of Molecular and Genomic Medicine |
| Abstract: | The pks gene cluster encodes enzymes responsible for the synthesis of colibactin, a genotoxin that has been shown to induce DNA damage and contribute to increased virulence. The present study investigated the prevalence of pks in clinical K. pneumoniae isolates from a national surveillance program in Taiwan, and identified microbiological and molecular factors associated with pks-carriage. The pks gene cluster was detected in 67 (16.7%) of 400 isolates from various specimen types. Multivariate analysis revealed that isolates of K1, K2, K20, and K62 capsular types (p < 0.001), and those more susceptible to antimicrobial agents (p = 0.001) were independent factors strongly associated with pks-carriage. Phylogenetic studies on the sequence type (ST) and pulsed-field gel electrophoresis patterns indicated that the pks-positive isolates belong to a clonal group of ST23 in K1, a locally expanding ST65 clone in K2, a ST268-related K20 group, and a highly clonal ST36:K62 group. Carriage of rmpA, iutC, and ybtA, the genes associated with hypervirulence, was significantly higher in the pks-positive isolates than the pks-negative isolates (95.5% vs. 13.2%, p < 0.001). Further studies to determine the presence of hypervirulent pks-bearing bacterial populations in the flora of community residents and their association with different disease entities may be warranted. |
| Date: | 2017-02-24 |
| Relation: | Scientific Reports. 2017 Feb 24;7:Article number 43120. |
| Link to: | http://dx.doi.org/10.1038/srep43120 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000394647000001 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85013844394 |
| Appears in Collections: | [楊采菱] 期刊論文
[其他] 期刊論文
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| SCP85013844394.pdf | | 1308Kb | Adobe PDF | 372 | View/Open |
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