國家衛生研究院 NHRI:Item 3990099045/10362
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    題名: Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells
    作者: Tsou, KL;Yount, JS;Hang, HC
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Increasing antibiotic resistance and beneficial effects of host microbiota has motivated the search for anti-infective agents that attenuate bacterial virulence rather than growth. For example, we discovered that specific flavonoids such as baicalein and quercetin from traditional medicinal plant extracts could attenuate Salmonella enterica serovar Typhimurium type III protein secretion and invasion of host cells. Here, we show epigallocatechin-3-gallate from green tea extracts also inhibits the activity of S. Typhimurium type III protein effectors and significantly reduces bacterial invasion into host cells. These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells.
    日期: 2017-06
    關聯: Bioorganic and Medicinal Chemistry. 2017 Jun;25(11):2883-2887.
    Link to: http://dx.doi.org/10.1016/j.bmc.2017.03.023
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0968-0896&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000404693600009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85015372251
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