國家衛生研究院 NHRI:Item 3990099045/10353

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10353

Title:	Optical interference-free surface-enhanced raman scattering CO-nanotags for logical multiplex detection of vascular disease-related biomarkers
Authors:	Gong, T;Hong, ZY;Chen, CH;Tsai, CY;Liao, LD;Kong, KV
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Matrix metalloproteinases (MMPs), specifically MMP-2, MMP-7, and MMP-9, have been discovered to be linked to many forms of vascular diseases such as stroke, and their detection is crucial to facilitate clinical diagnosis. In this work, we prepared a class of optical interference-free SERS nanotags (CO-nanotags) that can be used for the purpose of multiplex sensing of different MMPs. Multiplex detection with the absence of cross-talk was achieved by using CO-nanotags with individual tunable intrinsic Raman shifts of CO in the 1800-2200 cm-1 region determined by the metal core and ligands of the metal carbonyl complex. Boolean logic was used as well to simultaneously probe for two proteolytic inputs. Such nanotags offer the advantages of convenient detection of target nanotags and high sensitivity as validated in the ischemia rat model.
Date:	2017-02-28
Relation:	ACS Nano. 2017 Feb 28;11(3):3365-3375.
Link to:	http://dx.doi.org/10.1021/acsnano.7b00733
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1936-0851&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000398014900103
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85016304389
Appears in Collections:	[Lun-De Liao] Periodical Articles

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