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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10336


    Title: Roles of serum calcium, phosphorus, PTH and ALP on mortality in peritoneal dialysis patients: A nationwide, population-based longitudinal study using TWRDS 2005-2012
    Authors: Liu, CT;Lin, YC;Lin, YC;Kao, CC;Chen, HH;Hsu, CC;Wu, MS
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Biomarkers of chronic kidney disease-mineral and bone disorder (CKD-MBD) correlate with morbidity and mortality in dialysis patients. However, the comparative roles of each CKD-MBD biomarker remained undetermined on long-term peritoneal dialysis (PD) patients. This retrospective study, employing a population-based database, aimed to evaluate the performance and provide the best evidence of each biomarker of CKD-MBD as predictor of all-cause mortality. Throughout the 8-year study period, total 12,116 PD patients were included in this study. Cox proportional regression and Kaplan-Meier method were used for survival analysis. For Cox regression model, baseline measurements and time-varying covariates were used for analysis. In Cox regression model using time-dependent covariates, serum calcium level of >==9.5 mg/dL was associated with increased mortality. For phosphorus, serum levels of either >==6.5 mg/dL or <3.5 mg/dL were associated with increased mortality. For parathyroid hormone (PTH), higher serum levels were not associated increased mortality. For alkaline phosphatase (ALP), mortality increased at levels >==100 IU/L. Our findings suggested that the detrimental effect of ALP on survival was more consistent, while serum calcium, phosphorus and PTH may have a less prominent effect on mortality. This study provided additional information for manipulating CKD-MBD biomarkers in PD patients.
    Date: 2017-12
    Relation: Scientific Reports. 2017 Dec;7:Article number 33.
    Link to: http://dx.doi.org/10.1038/s41598-017-00080-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000396982900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029476803
    Appears in Collections:[許志成] 期刊論文

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