國家衛生研究院 NHRI:Item 3990099045/10309
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    题名: A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate
    作者: Yang, FL;Lou, TC;Kuo, SC;Wu, WL;Chern, J;Lee, YT;Chen, ST;Zou, W;Lin, NT;Wu, SH
    贡献者: Division of Infectious Diseases
    摘要: Concerns of Acinetobacter baumannii infection have increased due to the emergence of multi-drug resistance. In the present study, we determined the capsular polysaccharide (CPS) structure of A. baumannii SK44, a clinical isolate from Taiwan, to consist of pentasaccharide repeats. We found that CPS-induced antibody provided 55% protection against challenge in an animal model. The CPS-specific antibody reacted with the surface components of about 62% clinical isolates (342/554 strains) from cross-sectional and longitudinal studies by dot-immunoassay. Pulsed-field gel electrophoresis of positive strains showed the antibody covered different clonalites of A. baumannii clinical isolates. Meanwhile, using the CPS antibody as a probe, we found a number of outer membrane proteins bound to the antibody, including OmpA/motB, TonB-dependent receptor, and Omp38, indicating their association with CPS. These results might lead to the use of the capsular polysaccharide as a vaccine to prevent A. baumannii infection.
    日期: 2017-03-07
    關聯: Vaccine. 2017 Mar 7;3(10):1440-1447.
    Link to: http://dx.doi.org/10.1016/j.vaccine.2017.01.060
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0264-410X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000395611300012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85012863745
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