國家衛生研究院 NHRI:Item 3990099045/10255
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10255


    Title: Prognostic value of leptin receptor overexpression in upper tract urothelial carcinomas in Taiwan
    Authors: Lee, YC;Wu, WJ;Lin, HH;Li, WM;Huang, CN;Hsu, WC;Chang, LL;Li, CC;Yeh, HC;Li, CF;Ke, HL
    Contributors: National Institute of Cancer Research
    Abstract: AbstractObjectives Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). Materials and methods LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathological variables. Results LEPR expression was significantly correlated with patients with increased body mass index (BMI) (P < 0.001) and high serum creatinine levels (P = 0.005). We found, using the log-rank test, that high LEPR expression was associated with poor recurrence-free (P = 0.009) and cancer-specific survival (P = 0.001). This finding was supported by our results using Cox regression analysis, which showed that LEPR expression was an independent predictor of poor recurrence-free survival (hazard ratio = 2.55, P = 0.011) and cancer-specific survival (hazard ratio = 2.26, P = 0.006). Conclusions Our findings indicate that LEPR expression is a potential biomarker for predicting patient survival in UTUC. Further study is necessary to investigate the role of LEPR in carcinogenesis of upper tract urothelial carcinoma.
    Date: 2017-08
    Relation: Clinical Genitourinary Cancer. 2017 Aug;15(4):E653-E659.
    Link to: http://dx.doi.org/10.1016/j.clgc.2017.01.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1558-7673&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000407736900016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85011599034
    Appears in Collections:[Others] Periodical Articles

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