國家衛生研究院 NHRI:Item 3990099045/10228
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 924946      線上人數 : 973
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10228


    題名: Radiosurgical target distance from the Root Entry Zone in the treatment of trigeminal neuralgia
    作者: Sharim, J;Lo, WL;Kim, W;Chivukula, S;Tenn, S;Kaprealian, T;Pouratian, N
    貢獻者: NHRI Graduate Student Program
    摘要: Purpose Stereotactic radiosurgery (SRS) provides a noninvasive treatment modality to patients with medically refractory trigeminal neuralgia. The root entry zone (REZ) has been proposed to be an ideal stereotactic target due to its partial makeup of centrally produced myelin, conferring a theoretical increased sensitivity to irradiation, as well as increased susceptibility to neurovascular conflict, making it the site in which nociceptive signals likely arise. The aim of this study is to determine if there is a statistically and clinically significant difference in pain relief or facial hypesthesia following SRS based on distance of the stereotactic isocenter from REZ. Methods Patients undergoing Novalis radiosurgery for the treatment of trigeminal neuralgia with at least three months follow-up were included in this study. Post-operative outcomes were stratified by Barrow Neurological Institute (BNI) score for pain relief and BNI facial numbness score for facial hypesthesia. Results Sixty-seven patients met inclusion criteria and were included in this study. BNI score of I-IIIa was attained in 82% of patients at 3 months and 65% at 1 year following SRS. Distance from isocenter to REZ varied from 0 to 8.6 mm, with mean 1.94 ± 1.62 mm. Logistic regression of target-REZ distance against pain relief outcome (patients with score I-IIIa and IIIb-V) was insignificant at 3 months (p = 0.988), 6 months (p = 0.925), 9 months (p = 0.845), and 12 months (p = 0.547) post-operatively. Furthermore, no significant correlation was found with logistic regression of target-REZ distance with pain relief outcome (patients with score I and score II-IV) (p = 0.544). Conclusions The current analysis suggests that distance from REZ does not correlate with degree of post-operative pain relief or facial hypesthesia. Thus, targeting specific regions within the trigeminal nerve in relation to these anatomical characteristics may not afford any advantage from this perspective. Summary Stereotactic radiosurgery provides a noninvasive treatment modality to patients with medically refractory trigeminal neuralgia. The trigeminal REZ is a commonly used target due to its theoretical increased sensitivity to irradiation and neurovascular conflict. The current analysis suggests that distance from REZ does not correlate with degree of post-operative pain relief or facial hypesthesia. Targeting specific regions within the trigeminal nerve in relation to these anatomical characteristics may not afford any advantage from this perspective.
    日期: 2017-07
    關聯: Practical Radiation Oncology. 2017 Jul;7(4):221-227.
    Link to: http://dx.doi.org/10.1016/j.prro.2016.12.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1879-8500&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000416330300008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85015779210
    顯示於類別:[其他] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO1879850016303034.pdf743KbAdobe PDF376檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋