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http://ir.nhri.org.tw/handle/3990099045/10070
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| Title: | Physical activity for stroke prevention: Direct and indirect impact |
| Authors: | Wang, HK;Liu, CH;Jeng, JS;Hsu, SP;Chen, CH;Lien, LM;Chen, AC;Lee, JT;Chen, PK;Hsu, CS;Chern, CM;Chen, CC;Hsu, MC;Chen, HJ;Lu, K;Muo, CH;Hsu, CY;Wen, CP;Taiwan Stroke Registry Investigators |
| Contributors: | Division of Health Services and Preventive Medicine |
| Abstract: | Background and Rationale: The benefits of physical activity in stroke prevention are known, but received limited clinical attention. Revealing that exercise has a direct and indirect impact on various stages of stroke prevention may promote its everyday application. Methods: Two cohorts from Taiwan were used in the present study: The MJ Group medical screening program (MJ-cohort, N = 469,088, Lancet, 2011), recruited in 1994–2008, with individual activity data, and Taiwan Stroke Registry (TSR-cohort, N = 39,835, Circulation, 2010), recorded in 2006–2009. Cox model was used to calculate hazard ratios (HR). Results: Out of 11,804 deaths in the MJ-cohort, stroke constituted 7.7%, with 519 ischemic and 386 hemorrhagic stroke. Significant HR risks for stroke were smoking (1.56), hypertension (3.71), diabetes (1.36) and chronic kidney disease (1.69). Physical activity directly reduced stroke mortality by 34%, with 25% from hemorrhagic and 39% from ischemic stroke. Post-stroke exercise reduced all-cause mortality by 31% among those with previous stroke. In the TSR-cohort, physically active subjects had less severe stroke based on National Institutes of Health Stroke Scale on admission, fewer complications and better functional status at 3 months after stroke. Exercise also reduced stroke mortality in patients with risk factors to variable extent: hypertension (18%), CKD (6%), and smoking (5%). Conclusion: Physical activity, both pre-stroke and poststroke, should receive renewed clinical attention in all aspects of stroke prevention. Exercise reduced stroke complications and severity, improved post-stroke mortality and mitigating the effects of stroke risk factors before stroke. |
| Date: | 2016-07 |
| Relation: | Cerebrovascular Diseases. 2016 Jul;42(Suppl.):125. |
| Link to: | http://dx.doi.org/10.1159/000447732 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1015-9770&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000381107200265 |
| Appears in Collections: | [溫啟邦(2001-2010)] 會議論文/會議摘要
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| ISI000381107200265.pdf | | 74Kb | Adobe PDF | 324 | View/Open |
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