國家衛生研究院 NHRI:Item 3990099045/10036
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 907676      在线人数 : 936
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10036


    题名: Molecular mechanisms of DUSP22 ablation in enhancing EGFR-mediated lung tumor development: Potential involvement of immunosuppression
    作者: Lin, HP;Ho, HM;Chang, CW;Tan, TH;Lin, WJ
    贡献者: Immunology Research Center
    摘要: DUSP22, a member of the dual-specificity phosphatases (DUSPs) family, is a key phosphatase controlling the activity of protein kinases and transcription factors through the dephosphorylation (serine/threonine or tyrosine) process, such as MAPKs, FAK, Lck, and STAT3. Many members of DUSP22-targeted proteins are important for tumorigenesis, and DUSP22 downregulation has been reported in some cancers. Importantly, DUSP22 -/- mice manifest multi-organ inflammation, supporting a role for DUSP22 in maintaining immune homeostasis. However, little is known about the in vivo role of DUSP22 during tumor development. Here, utilizing a murine lung tumor model driven by the combination of mutated EGFR amplification (exon 19 deletion) and the loss of DUSP22, we found genetic ablation of DUSP22 promoted aggressive EGFR-mediated lung tumor development at early age, and identified MDSCs and exhausted T cells as the two main tumor-infiltrating immune cell types. Our cytokine array profiling found a significant increase of IL-1 and CXCL1 in EGFR/DUSP22 KO lung tumors, suggesting these two cytokines may potentially serve as EGFR/DUSP22 KO tumor-derived factors to attract immuosuppressive cells and promote tumor development. Consistently, GEO data analysis shows that lung adenocarcinoma patients with low DUSP22 expression have poor survival. Collectively, our current data indicate that DUSP22 underexpression may facilitate the recruitment of MDSCs and dysfunctional T cells and establish an immunosuppressive tumor microenvironment for tumor development. Currently, we are using pharmacological and immune approach to elucidate molecular mechanisms of DUSP22 ablation for enhancing lung tumor development.
    日期: 2016-08
    關聯: European Journal of Immunology. 2016 Aug;46(Suppl. 1):240.
    Link to: http://dx.doi.org/10.1002/eji.201670200
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383610400485
    显示于类别:[林文傑] 會議論文/會議摘要
    [譚澤華] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000383610400485.pdf189KbAdobe PDF492检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈