國家衛生研究院 NHRI:Item 3990099045/10031
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    題名: Hydrogels bearing bioengineered mimetic embryonic microenvironments for tumor reversion
    作者: Zhao, Y;Yan, H;Qiao, S;Zhang, L;Wang, T;Meng, Q;Chen, X;Lin, FH;Guo, K;Li, C;Tian, W
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Embryonic microenvironments can reverse the metastatic phenotype of aggressive tumors by inhibiting the Nodal signaling pathway. Here, we hypothesize that embryonic microenvironments can be transplanted for the purpose of oncotherapy. We report the development of an injectable bioactive hydrogel system containing the key antagonists of Nodal signaling - Cripto-1 receptor antibodies (2B11) - for the creation of embryonic microenvironments and the examination of their effect on tumor reversion treatment using a mouse model. Our in vitro results show that the hydrogel system can reduce the mitochondrial membrane potential of MDA-MB-231 and MCF-7, promote cell apoptosis, and reduce the invasive ability of cells. Our in vivo results illustrate that the hydrogel system can significantly inhibit tumor growth in both breast cancer and melanoma tumor-bearing mouse models, as well as transform the cell morphology of melanoma B16 cells to melanin-like cells. Furthermore, the results of the up-regulation of tumor suppressor genes and the down-regulation of oncogenes by high-throughput sequencing confirm that the developed system can also selectively turn on some tumor suppressor genes and turn off certain oncogenes so as to prompt the benign reversion of the tumor phenotype. Taken together, our results demonstrate the injectable biomaterial system is able to create an effective microenvironment for melanoma and breast tumor therapy.
    日期: 2016-10-07
    關聯: Journal of Materials Chemistry B. 2016 Oct 07;4(37):6183-6191.
    Link to: http://dx.doi.org/10.1039/c6tb00927a
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000384444800003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84988850656
    顯示於類別:[林峯輝] 期刊論文

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