國家衛生研究院 NHRI:Item 3990099045/10017
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    题名: The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
    作者: Ehret, GB;Ferreira, T;Chasman, DI;Jackson, AU;Schmidt, EM;Johnson, T;Thorleifsson, G;Luan, J;Donnelly, LA;Kanoni, S;Petersen, AK;Pihur, V;Strawbridge, RJ;Shungin, D;Hughes, MF;Meirelles, O;Kaakinen, M;Bouatia-Naji, N;Kristiansson, K;Shah, S;Kleber, ME;Guo, X;Lyytikainen, LP;Fava, C;Eriksson, N;Nolte, IM;Magnusson, PK;Salfati, EL;Rallidis, LS;Theusch, E;Smith, AJ;Folkersen, L;Witkowska, K;Pers, TH;Joehanes, R;Kim, SK;Lataniotis, L;Jansen, R;Johnson, AD;Warren, H;Kim, YJ;Zhao, W;Wu, Y;Tayo, BO;Bochud, M;Absher, D;Adair, LS;Amin, N;Arking, DE;Axelsson, T;Baldassarre, D;Balkau, B;Bandinelli, S;Barnes, MR;Barroso, I;Bevan, S;Bis, JC;Bjornsdottir, G;Boehnke, M;Boerwinkle, E;Bonnycastle, LL;Boomsma, DI;Bornstein, SR;Brown, MJ;Burnier, M;Cabrera, CP;Chambers, JC;Chang, IS;Cheng, CY;Chines, PS;Chung, RH;Collins, FS;Connell, JM;Doring, A;Dallongeville, J;Danesh, J;de Faire, U;Delgado, G;Dominiczak, AF;Doney, AS;Drenos, F;Edkins, S;Eicher, JD;Elosua, R;Enroth, S;Erdmann, J;Eriksson, P;Esko, T;Evangelou, E;Evans, A;Fall, T;Farrall, M;Felix, JF;Ferrieres, J;Ferrucci, L;Fornage, M;Chang, IS;Chung, RH;Hsiung, CA;et, al
    贡献者: National Institute of Cancer Research;Division of Biostatistics and Bioinformatics
    摘要: To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
    日期: 2016-09-12
    關聯: Nature Genetics. 2016 Sep 12;48(10):1171-1184.
    Link to: http://dx.doi.org/10.1038/ng.3667
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1061-4036&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000384391600012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84987625495
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