Results: Among the 8968 patients with FIGO stage I to IVuterine cervical cancer, 3607 patients (40%) were treated with chemoradiation therapy/ radiation therapy as initial treatment. Seventy-six percent (n Z 2751) of these patients were treated with curative radiation dose. The median time of whole radiation therapy course was 60 days (interquartile range Z 53, 69 months). The significant poor prognostic factors related to cancer specific survival (CSS) and overall survival (OS) included old age, non-squamous cancer type, high grade histology, larger tumor size, advanced FIGO stage, low hospital volume of patients’ treatment sites, and prolonged overall treatment time. After multivariate analysis with significant factors mentioned above, prolonged treatment time remained poor impact on both CSS (HR: 1.26; P Z 0.05) and OS (HR: 1.13; P Z 0.07). Every additional day more than 56 days decreased the 3-year overall survival rate by 0.8%. Further subgroup analysis disclosed that the 5-year overall survival rate for <=/ > 56 days of FIGO stage I-II and stage III-IV patients were 81% / 70% (P <0.01) and 43% / 42% (P Z 0.92), respectively. Conclusion: Prolonged treatment time of definitive CRT or RT alone for cervical cancer is detrimental for cancer specific survival and overall survival. Completion of radiation therapy treatment within eight weeks is highly recommended, especially for patients with FIGO stage I-II disease.
Date:
2016-10-01
Relation:
International Journal of Radiation Oncology, Biology, Physics. 2016 Oct 1;96(2S, Suppl.):E301.
