國家衛生研究院 NHRI:Item 3990099045/10010
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    题名: MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the foxp3 transcription factor
    作者: Yang, HY;Barbi, J;Wu, CY;Zheng, Y;Vignali, PDA;Wu, XM;Tao, JH;Park, BV;Bandara, S;Novack, L;Ni, XH;Yang, XP;Chang, KY;Wu, RC;Zhang, JR;Yang, CW;Pardoll, DM;Li, HB;Pan, F
    贡献者: National Institute of Cancer Research
    摘要: Regulatory T (Treg) cells are important in maintaining self-tolerance and immune homeostasis. The Treg cell transcription factor Foxp3 works in concert with other co-regulatory molecules, including Eos, to determine the transcriptional signature and characteristic suppressive phenotype of Treg cells. Here, we report that the inflammatory cytokine interleukin-6 (IL-6) actively repressed Eos expression through microRNA-17 (miR-17). miR-17 expression increased in Treg cells in the presence of IL-6, and its expression negatively correlated with that of Eos. Treg cell suppressive activity was diminished upon overexpression of miR-17 in vitro and in vivo, which was mitigated upon co-expression of an Eos mutant lacking miR-17 target sites. Also, RNAi of miR-17 resulted in enhanced suppressive activity. Ectopic expression of miR-17 imparted effector-T-cell-like characteristics to Treg cells via the derepression of genes encoding effector cytokines. Thus, miR-17 provides a potent layer of Treg cell control through targeting Eos and additional Foxp3 co-regulators.
    日期: 2016-07-19
    關聯: Immunity. 2016 Jul 19;45(1):83-93.
    Link to: http://dx.doi.org/10.1016/j.immuni.2016.06.022
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1074-7613&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380749000012
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