| [謝興邦] 期刊論文 |
2006-10 |
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents |
- |
 |
| [葉燈光] 期刊論文 |
2006-11-25 |
The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes |
- |
|
| [陳炯東] 期刊論文 |
2006-12 |
Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats |
- |
|
| [謝興邦] 期刊論文 |
2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
- |
|
| [葉燈光] 期刊論文 |
2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
- |
|
| [林嬪嬪] 期刊論文 |
2007-09 |
Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment |
- |
|
| [葉燈光] 期刊論文 |
2007-09-15 |
Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry |
- |
|
| [林嬪嬪] 會議論文/會議摘要 |
2007-10 |
Differential effects of arsenic on cyp1 enzymes in vitro and in vivo |
- |
|
| [葉燈光] 期刊論文 |
2007-10-01 |
Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry |
- |
|
| [葉燈光] 期刊論文 |
2008-02 |
The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes |
- |
|
| [葉燈光] 期刊論文 |
2008-02-28 |
Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet |
- |
|
| [葉燈光] 期刊論文 |
2008-05 |
High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine |
- |
|
| [葉燈光] 期刊論文 |
2008-07 |
Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice |
- |
|
| [陳炯東] 期刊論文 |
2008-07-09 |
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice |
- |
|
| [林嬪嬪] 期刊論文 |
2009-02 |
Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: An in vitro and in vivo study |
- |
|
| [蔣維棠] 期刊論文 |
2009-03-15 |
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors |
- |
|
| [蔣維棠] 期刊論文 |
2009-04-01 |
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors |
- |
|
| [張俊彥] 期刊論文 |
2009-04-17 |
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents |
- |
|
| [葉燈光] 期刊論文 |
2009-07 |
Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes |
- |
|
| [陳新(2002-2015)] 期刊論文 |
2009-07-15 |
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor |
- |
|
| [夏克山] 期刊論文 |
2009-07-23 |
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice |
- |
|
| [謝興邦] 期刊論文 |
2009-08-13 |
Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach |
- |
|
| [陳炯東] 期刊論文 |
2010-02 |
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 |
- |
|
| [陳新(2002-2015)] 期刊論文 |
2010-06-15 |
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-07 |
Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-08 |
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein |
- |
|
| [夏克山] 期刊論文 |
2010-09 |
Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-09-01 |
Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors |
- |
|
| [洪明秀] 期刊論文 |
2010-10 |
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-11 |
Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus |
- |
|
| [陳炯東] 期刊論文 |
2011-01 |
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2011-01-13 |
Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes |
- |
|
| [楊重熙] 期刊論文 |
2011-03 |
Comparative tissue distributions of cadmium chloride and cadmium-based quantum dot 705 in mice: Safety implications and applications |
- |
|
| [葉燈光] 期刊論文 |
2011-03 |
Effect of shengmai san on insulin resistance, tumor necrosis factor-alpha and oxidative stress in rats fed on a high-fat diet |
- |
|
| [徐祖安] 會議論文/會議摘要 |
2011-03 |
Potent EGFR tyrosine kinase inhibitors as anticancer agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors |
- |
|
| [謝興邦] 期刊論文 |
2011-04-28 |
Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents |
- |
|
| [蔣維棠] 期刊論文 |
2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
- |
|
| [張俊彥] 期刊論文 |
2011-08 |
BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells |
- |
|
| [葉燈光] 專利 |
2011-09-27 |
Formulations of indol-3-yl-2-oxoacetamide compounds |
- |
|
| [岳嶽] 期刊論文 |
2012-01 |
Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor |
- |
|
| [徐祖安] 期刊論文 |
2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
- |
|
| [葉燈光] 期刊論文 |
2012-02-01 |
Kinetics and tissue distribution of neutron-activated zinc oxide nanoparticles and zinc nitrate in mice: Effects of size and particulate nature |
- |
|
| [葉燈光] 期刊論文 |
2012-04 |
Synthesis and biological evaluation of 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo |
- |
|
| [葉燈光] 期刊論文 |
2012-06 |
Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats |
- |
|
| [蔣維棠] 期刊論文 |
2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
- |
|
| [李靜琪] 期刊論文 |
2012-09 |
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors |
- |
|
| [謝興邦] 期刊論文 |
2012-09 |
Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization |
- |
|
| [趙宇生(2002-2013)] 會議論文/會議摘要 |
2012-11 |
BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia |
- |
|
| [葉燈光] 期刊論文 |
2012-12-13 |
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity |
- |
|
| [謝興邦] 期刊論文 |
2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor |
- |
|
| [夏克山] 專利 |
2013-01-15 |
Imidazol-4-one and imidazole-4-thione compounds |
- |
|
| [岳嶽] 期刊論文 |
2013-02 |
Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
- |
|
| [葉燈光] 專利 |
2013-02-11 |
抗癌口服藥學組成物 |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112 |
- |
|
| [李秀珠] 會議論文/會議摘要 |
2013-04-13 |
Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents |
- |
|
| [蔣維棠] 期刊論文 |
2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
- |
|
| [葉燈光] 專利 |
2013-06-05 |
Anticancer oral formulation |
- |
|
| [鄒小蕙] 期刊論文 |
2013-07 |
CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions |
- |
|
| [葉燈光] 期刊論文 |
2013-07-08 |
1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors |
- |
|
| [葉燈光] 期刊論文 |
2013-07-08 |
Inside Cover: 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors(ChemBioChem 10/2013) |
- |
|
| [葉燈光] 期刊論文 |
2013-11 |
BPR0C305, an orally active microtubule-disrupting anticancer agent |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2013-11 |
A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 |
- |
|
| [夏克山] 期刊論文 |
2013-11-13 |
Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice |
- |
|
| [徐祖安] 期刊論文 |
2014-01-08 |
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer |
- |
|
| [徐祖安] 會議論文/會議摘要 |
2014-03 |
DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study |
- |
|
| [張俊彥] 期刊論文 |
2014-04 |
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones |
- |
|
| [夏克山] 專利 |
2014-04-21 |
咪唑-4-酮及咪唑-4-硫酮化合物 |
- |
|
| [張俊彥] 期刊論文 |
2014-05 |
Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells |
- |
|
| [葉燈光] 專利 |
2014-06-04 |
抗癌口服制剂 |
- |
|
| [葉燈光] 專利 |
2014-08-15 |
Anticancer oral formulation |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-10 |
Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-11 |
Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent |
- |
|
| [夏克山] 專利 |
2014-11-19 |
咪唑-4-酮及咪唑-4-硫酮化合物 |
- |
|
| [葉燈光] 期刊論文 |
2015-01 |
1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells |
- |
|
| [蔣維棠] 期刊論文 |
2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations |
- |
|
| [郭靜娟] 期刊論文 |
2015-08 |
Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2015-08 |
Zinc-dipicolylamine directed pharmaceutical delivery system (ZAPS) as an innovative cancer drug delivery platform |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2015-08 |
Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia |
- |
|
| [伍素瑩] 期刊論文 |
2015-10 |
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening |
- |
|
| [張俊彥] 期刊論文 |
2016-01 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition |
- |
|
| [翁紹華] 期刊論文 |
2016-01 |
Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy |
- |
|
| [李靜琪] 期刊論文 |
2016-05 |
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors |
- |
|
| [葉燈光] 期刊論文 |
2016-07 |
In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71 |
- |
|
| [葉燈光] 期刊論文 |
2016-09 |
Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice |
- |
|
| [謝興邦] 期刊論文 |
2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
- |
|
| [洪明秀] 會議論文/會議摘要 |
2016-12 |
Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2016-12 |
Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST |
- |
|
| [翁紹華] 期刊論文 |
2017-01 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists |
- |
|
| [陳志豪] 期刊論文 |
2017-01 |
A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
- |
|
| [翁紹華] 期刊論文 |
2017-05 |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine |
- |
|
| [李秀珠] 期刊論文 |
2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors |
- |
|
| [鄒倫] 期刊論文 |
2017-07 |
Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates |
- |
|
| [謝興邦] 期刊論文 |
2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer |
- |
|
| [李靜琪] 期刊論文 |
2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 |
- |
|
| [夏克山] 期刊論文 |
2018-02-08 |
Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond |
- |
|
| [翁紹華] 期刊論文 |
2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy |
- |
|
| [張俊彥] 期刊論文 |
2018-06-15 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.] |
- |
|
| [翁紹華] 會議論文/會議摘要 |
2018-07 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo |
- |
|
| [葉燈光] 期刊論文 |
2018-08-23 |
5-aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating alzheimer's disease phenotypes |
- |
|
| [李靜琪] 期刊論文 |
2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors |
- |
|
| [陳志豪] 期刊論文 |
2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
- |
|
| [伍素瑩] 期刊論文 |
2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants |
- |
|
| [葉燈光] 期刊論文 |
2019-05 |
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents |
- |
|
| [葉燈光] 期刊論文 |
2019-06-05 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
- |
|
| [紀雅惠] 會議論文/會議摘要 |
2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer |
- |
|
| [鄒倫] 期刊論文 |
2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
- |
|
| [謝興邦] 期刊論文 |
2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
- |
|
| [蔣維棠] 期刊論文 |
2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
- |
|
| [葉燈光] 期刊論文 |
2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment |
- |
|
| [伍素瑩] 期刊論文 |
2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors |
- |
|
| [劉滄梧] 期刊論文 |
2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system |
- |
|
| [葉修華] 期刊論文 |
2020-04 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine |
- |
|
| [謝興邦] 期刊論文 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
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| [陳炯東] 期刊論文 |
2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
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| [李秀珠] 期刊論文 |
2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
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| [石全(2014-2017)] 會議論文/會議摘要 |
2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification |
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| [謝興邦] 期刊論文 |
2021-01 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors |
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| [鄒倫] 期刊論文 |
2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
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| [蔣維棠] 期刊論文 |
2021-01 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease |
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| [夏克山] 期刊論文 |
2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment |
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| [紀雅惠] 期刊論文 |
2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins |
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| [陳炯東] 期刊論文 |
2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
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| [謝興邦] 期刊論文 |
2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
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| [謝興邦] 期刊論文 |
2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
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| [翁紹華] 期刊論文 |
2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design |
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| [鄒倫] 期刊論文 |
2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates |
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| [張俊彥] 期刊論文 |
2022-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy |
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| [鄒倫] 期刊論文 |
2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids |
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| [鄒倫] 期刊論文 |
2022-07 |
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate |
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| [其他] 期刊論文 |
2022-07-24 |
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice |
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| [夏克山] 期刊論文 |
2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention |
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| [陳炯東] 期刊論文 |
2022-10-13 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate |
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| [翁紹華] 期刊論文 |
2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation |
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| [葉燈光] 期刊論文 |
2022-12-05 |
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors |
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| [謝興邦] 期刊論文 |
2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
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| [謝興邦] 會議論文/會議摘要 |
2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs |
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| [李靜琪] 期刊論文 |
2023-10-05 |
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease |
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| [葉修華] 期刊論文 |
2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects |
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| [紀雅惠] 期刊論文 |
2024-06-01 |
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus |
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| [謝興邦] 期刊論文 |
2024-06-24 |
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment |
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| [黃智興] 期刊論文 |
2024-07-04 |
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells |
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| [葉修華] 期刊論文 |
2024-07-17 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |
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| [廖玉潔] 期刊論文 |
2024-08-19 |
Tracing the footprints of MPXV in Asia: Phylogenetic insights and lineage dynamics |
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| [葉修華] 期刊論文 |
2024-11 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
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