國家衛生研究院 NHRI:Browse by Title
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    Showing items 3551-3560 of 12927. (1293 Page(s) Totally)
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    DateTitleRelation
    2009-03 Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors Abstracts of Papers - American Chemical Society. 2009 Mar;237:MEDI 221.
    2016-04 Discovery and development of tylophorine derived dibenzoquinolines-33b compounds into therapeutic agents The FASEB Journal. 2016 Apr;30(1, Suppl.):Meeting Abstract lb56.
    2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 .
    2013-11 Discovery and refinement of loci associated with lipid levels Nature Genetics. 2013 Nov;45(11):1274-1283.
    2014-08 Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
    2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
    2010-09 Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist ChemMedChem. 2010 Sep;5(9):1439-1443.
    2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
    2015-08 Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors Abstracts of Papers of the American Chemical Society. 2015 Aug;250:Meeting Abstract 182.
    2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
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